Xenograft models of chronic lymphocytic leukemia: problems, pitfalls and future directions
نویسندگان
چکیده
منابع مشابه
B-Cell Chronic Lymphocytic Leukemia: Present Status and Future Directions
INCE TURKS’ initial identification of chronic lymphoS cytic leukemia (CLL), Minot and Isaacs” description of its clinical features in 1924, and Dameshek‘? hypothesis in 1967, considerable progress in the understanding of CLL has been achieved, especially during the last two decades. The purpose of the present work is to review the major advances in the biology and clinical research of CLL and t...
متن کاملB-cell chronic lymphocytic leukemia: present status and future directions. French Cooperative Group on CLL.
INCE TURKS’ initial identification of chronic lymphoS cytic leukemia (CLL), Minot and Isaacs” description of its clinical features in 1924, and Dameshek‘? hypothesis in 1967, considerable progress in the understanding of CLL has been achieved, especially during the last two decades. The purpose of the present work is to review the major advances in the biology and clinical research of CLL and t...
متن کاملChronic lymphocytic leukemia, biology, new diagnosis and treatment: review article
Chronic lymphocytic leukemia (CLL) is a malignancy of B CD5+cells and is the most common type of leukemia in adults. The disease is more common in men over 50 years in western countries. CLL is associated with defective apoptosis in B cells. CLL was traditionally regarded as a disease that occurs before naïve B cells meet the antigen in the lymph nodes. Laboratory diagnosis requires white blood...
متن کاملMouse Models of Chronic Lymphocytic Leukemia
Genetically modified mice mimicking the expression of candidate genes implicated in the etiology of disease are essential tools not only to demonstrate the role of these genes in disease, but also as preclinical platforms for testing new therapies. The absence of mouse models of CLL was a problem hindering CLL research for long time. This problem was exacerbated because the development of xenog...
متن کاملCD38 gene polymorphisms and genetic susceptibility to chronic lymphocytic leukemia
Introduction: CLL is one of the most common leukemias, which is categorized by the accumulation of mature CD5+ B-lymphocytes in the peripheral blood, bone marrow, and secondary lymphoid organs. In this study, the status of rs6449182 polymorphism of the CD38 gene and its association with clinical and laboratory parameters of CLL patients was evaluated. Methods: Genomic DNA extraction was perfor...
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ژورنال
عنوان ژورنال: Leukemia
سال: 2012
ISSN: 0887-6924,1476-5551
DOI: 10.1038/leu.2012.268